Tuesday, July 25, 2023

Treating Severe Xerosis with Urea-based Moisturizers

Dear Dr. Renukaprasad A R,
In patients with diabetes mellitus (DM), skin xerosis, calluses, and fissures present on the shins and feet may result in the development of ulcers. Effective foot care for people with diabetes includes regular moisturizing as a key preventive measure.1
Urea, a natural moisturizing factor, is a potent emollient and keratolytic agent. Arginine improves microcirculation, while urea and carnosine inhibit the formation and accumulation of advanced glycated end products. Collectively, these ingredients improve skin hydration.1
Check out this exclusive Journal Watch, where we have summarized a randomized, 8-month, assessor-blinded, controlled study where the efficacy of urea, arginine, and carnosine-based cream for severe foot xerosis in DM patients was evaluated.
Reference
  1. Federici A et al., Curr Med Res Opin. 2015 Jun;31(6):1063-9.
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